Natural End — ruling 1

If the target artifact or enchantment is an illegal target by the time Natural End tries to resolve, the spell doesn’t resolve. You don’t gain life. If the target is legal but not destroyed (most likely because it has indestructible), you do gain life.

Natural End : règles, fonctionnement et interactions (MTG)

Natural End is one of those cards players keep asking about. Here is, in plain words, what its official text says, the rulings published by Wizards of the Coast, and the combos players actually run.

Official card text

Destroy target artifact or enchantment. You gain 3 life.

How it works : Natural End

Original English text — Wizards of the Coast / Scryfall

#1July 12, 2019· Wizards of the Coast
If the target artifact or enchantment is an illegal target by the time Natural End tries to resolve, the spell doesn’t resolve. You don’t gain life. If the target is legal but not destroyed (most likely because it has indestructible), you do gain life.
No other card is named in this ruling.