Pistus Strike — ruling 1

If the creature with flying regenerates or has indestructible, its controller will still get a poison counter.

Pistus Strike — ruling 2

If the creature is an illegal target when Pistus Strike tries to resolve, the spell doesn’t resolve. No player gets a poison counter.

Pistus Strike : règles, fonctionnement et interactions (MTG)

Pistus Strike is one of those cards players keep asking about. Here is, in plain words, what its official text says, the rulings published by Wizards of the Coast, and the combos players actually run.

Official card text

Destroy target creature with flying. Its controller gets a poison counter.

How it works : Pistus Strike

Original English text — Wizards of the Coast / Scryfall

#1July 1, 2013· Wizards of the Coast
If the creature with flying regenerates or has indestructible, its controller will still get a poison counter.
Card named in this ruling
Poison Counter
#2June 1, 2011· Wizards of the Coast
If the creature is an illegal target when Pistus Strike tries to resolve, the spell doesn’t resolve. No player gets a poison counter.
Card named in this ruling
Poison Counter