Toxic Nim is one of those cards players keep asking about. Here is, in plain words, what its official text says, the rulings published by Wizards of the Coast, and the combos players actually run.
Official card text
Infect (This creature deals damage to creatures in the form of -1/-1 counters and to players in the form of poison counters.): Regenerate this creature.
Complete guide
Toxic Nim is a relentless Phyrexian Zombie that embodies the terrifying efficiency of the New Phyrexia invasion. By combining the lethal Infect mechanic with the ability to survive combat, it serves as a potent threat that can end games in just a few swings. Understanding how its defensive regeneration interacts with its offensive counters is key to mastering this creature.
How Infect Works
Toxic Nim does not deal damage like a normal creature. When it deals damage to a player, that player gains that many poison counters instead of losing life; ten poison counters result in a loss for that player. When it deals damage to a creature, it places that many -1/-1 counters on it, which remain on the creature even if it survives the combat, permanently weakening it or killing it if its toughness reaches zero.
The Art of Regeneration
By paying one black mana, you create a 'regeneration shield' for Toxic Nim that lasts for the duration of the current turn. The next time the Nim would be destroyed that turn, it isn't. Instead, it is tapped, all damage is removed from it, and if it was in combat, it is removed from combat. Note that this does not return it from the graveyard; you must activate the ability before the destruction event occurs.
Synergy and Strategy
Toxic Nim shines in decks that care about the graveyard or high devotion to black. Because it can protect itself from being destroyed, it is a reliable permanent to keep on the board for effects that count black mana symbols. Additionally, its status as a Zombie allows it to synergize with various tribal effects common in black decks.
Common Mistakes
A common error is trying to regenerate Toxic Nim after it has already been put into the graveyard. Regeneration must be activated while the creature is on the battlefield, before the lethal damage or destruction effect resolves. Also, remember that regeneration does not protect against 'sacrifice' effects or effects that reduce toughness to zero (like -1/-1 counters), as those do not 'destroy' the creature.
Interaction examples
If Toxic Nim attacks an opponent directly and is not blocked, it deals 4 damage. Instead of the opponent losing 4 life, they receive 4 Poison Counter objects. If they reach 10 of these, they lose the game immediately, regardless of their current life total.
Toxic Nim has two black mana symbols in its cost. When you play Gray Merchant of Asphodel, Toxic Nim contributes 2 to your devotion to black. Because Toxic Nim can regenerate for one black mana, you can reliably keep it on the board to ensure your Gray Merchant always has a high impact.
If an opponent attempts to destroy Toxic Nim with a spell, you can respond by paying one black mana to regenerate it. Toxic Nim stays on the battlefield, so Syr Konrad, the Grim will not trigger. However, if you choose not to regenerate and Toxic Nim dies, Syr Konrad, the Grim will trigger and deal 1 damage to each opponent.
Guide written with AI from the official text and rulings. Official English text prevails.
How it works : Toxic Nim
Original English text — Wizards of the Coast / Scryfall
No additional ruling has been published for this card.
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Meta decks with Toxic Nim
No archived Top 8 deck with this card yet.



Poison Counter
Gray Merchant of Asphodel
Syr Konrad, the Grim