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MutagenHow it works & interactions with other cards

By the ManaCount desk· 2 min read· Teenage Mutant Ninja Turtles Tokens· March 6, 2026
Carte Magic Mutagen

Mutagen is one of those cards players keep asking about. Here is, in plain words, what its official text says, the rulings published by Wizards of the Coast, and the combos players actually run.

01

Official card text

{1}, {T}, Sacrifice this token: Put a +1/+1 counter on target creature. Activate only as a sorcery.

How it works : Mutagen

Original English text — Wizards of the Coast / Scryfall

No additional ruling has been published for this card.

02

Interactions with other cards

These cards' text mentions Mutagen.

The Ooze
The Ooze

Whenever a creature you control with a +1/+1 counter on it leaves the battlefield, create a Mutagen token for each +1/+1 counter on it. (A Mutagen token is an artifact with "{1}, {T}, Sacrifice this token: Put a +1/+1 counter on target creature. Activate only as a sorcery.") {T}: Exile target card from a graveyard. Create a Mutagen token.

Michelangelo, Weirdness to 11
Michelangelo, Weirdness to 11

When Michelangelo enters, create a Mutagen token. (It's an artifact with "{1}, {T}, Sacrifice this token: Put a +1/+1 counter on target creature. Activate only as a sorcery.") If one or more +1/+1 counters would be put on a creature you control, that many plus one +1/+1 counters are put on it instead.

Mutagen Man, Living Ooze
Mutagen Man, Living Ooze

Trample Activated abilities of artifact tokens you control cost {1} less to activate. When Mutagen Man enters, create X Mutagen tokens. (They're artifacts with "{1}, {T}, Sacrifice this token: Put a +1/+1 counter on target creature. Activate only as a sorcery.")

Donatello, the Brains
Donatello, the Brains

If one or more tokens would be created under your control, those tokens plus a Mutagen token are created instead. Partner—Character select (You can have two commanders if both have this ability.)

Raphael, the Muscle
Raphael, the Muscle

Double all damage that creatures you control with counters on them would deal. When Raphael enters, create a Mutagen token. Partner—Character select (You can have two commanders if both have this ability.)

Splinter, the Mentor
Splinter, the Mentor

Menace Whenever Splinter or another nontoken creature you control leaves the battlefield, create a Mutagen token. Partner—Character select (You can have two commanders if both have this ability.)

Michelangelo, Mutant BFF
Michelangelo, Mutant BFF

Each creature you control with a counter on it can't be blocked by more than one creature. Whenever Michelangelo enters or attacks, create a Mutagen token. (It's an artifact with "{1}, {T}, Sacrifice this token: Put a +1/+1 counter on target creature. Activate only as a sorcery.")

Shellshock
Shellshock

For each opponent, choose up to one target creature that player controls. Shellshock deals X damage to each of those creatures. You create a Mutagen token for each creature dealt damage this way. (They're artifacts with "{1}, {T}, Sacrifice this token: Put a +1/+1 counter on target creature. Activate only as a sorcery.")

April O'Neil, Human Element
April O'Neil, Human Element

Whenever a player casts an artifact, instant, or sorcery spell, you create a Mutagen token. (It's an artifact with "{1}, {T}, Sacrifice this token: Put a +1/+1 counter on target creature. Activate only as a sorcery.")

Roadkill Rodney
Roadkill Rodney

Squad {3} (As an additional cost to cast this spell, you may pay {3} any number of times. When this creature enters, create that many tokens that are copies of it.) Deathtouch Whenever this creature deals combat damage to a player, create a Mutagen token.

Mona Lisa, Ever Adaptable
Mona Lisa, Ever Adaptable

Whenever a player casts a creature spell, you create a Mutagen token. (It's an artifact with "{1}, {T}, Sacrifice this token: Put a +1/+1 counter on target creature. Activate only as a sorcery.")

Ooze Spill
Ooze Spill

Counter target spell. Create a Mutagen token. (It's an artifact with "{1}, {T}, Sacrifice this token: Put a +1/+1 counter on target creature. Activate only as a sorcery.")

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Meta decks with Mutagen

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